Research in our group focuses on understanding how nutrient transporters function at a molecular level. In humans, many of the membrane proteins involved in absorbing nutrients from our diet are also responsible for drug transport and distribution into specific organs, including the central nervous system, liver, kidneys and GI tract. Nutrient transporters therefore have a profound impact on the pharmacokinetic properties of many administered drugs with clear medical advantages in understanding their structure, biochemistry and regulation.
The primary overarching interest of the lab is the discovery and characterisation of transporters in bacteria. For over a decade our main experimental system has been a family of transporters called the TRAP transporters, which stand for tripartite ATP-independent periplasmic transporters. These transporters are found all over the bacteria world and have important functions in many environments, primarily as organic acid transporters of high affinity.
The molecular basis of thioalcohol production in human body odour
Michelle Rudden, Reyme Herman, Matthew Rose, Daniel Bawdon, Diana S. Cox, Eleanor Dodson, Matthew T. G. Holden, Anthony J. Wilkinson, A. Gordon James & Gavin H. Thomas
Structural basis of malodour precursor transport in the human axilla
Gurdeep S Minhas, Daniel Bawdon, Reyme Herman, Michelle Rudden, Andrew P Stone, A Gordon James, Gavin H Thomas & Simon Newstead.
Identification of axillary Staphylococcus sp. involved in the production of the malodorous thioalcohol 3-methyl-3-sufanylhexan-1-ol
Daniel Bawdon, Diana S. Cox, David Ashford, A. Gordon James, Gavin H. Thomas
Most of us don’t need more than one whiff to identify that generally unpleasant, characteristic smell we call body odor. But it’s a surprisingly complex phenomenon, influenced by our genetic makeup, age, diet, and hygiene. So what is this odor, exactly? Where does it come from? And can we do anything about it? Mel Rosenberg dives into the stinky science of body odor.